New potentiometric monitoring devices for trace and fast determination of three imidazole derivatives were presented. The sensing materials were fabricated by the inclusion of imidazolinium phosphomolybdate (Imd/PMA) (sensor I), imidazolinium tetraphenylborate (Imd/TPB) (sensor II), or dibenzo-24-crown-8 (DB24C8) (sensor III) in the plasticized polyvinyl chloride (PVC) matrix. The sensors showed clear enhanced response towards imidazolium [Imd+] ions over the concentration range 4.0 × 10−6–1 × 10−2 mol L−1 at pH 5 with 0.42 μg mL−1 as a detection limit. The selectivity was tested with various inorganic and nitrogenous organic ions. Long life span, fast response, long-term stability, and high reproducibility are shown for the sensors. Method validation for the proposed method was achieved by quantifying the detection limit, linear range, accuracy, precision, repeatability, and between-day variability. It revealed good performance characteristics of the proposed sensors. The applicability of the sensors for analyzing imidazole in urine samples was successfully demonstrated via recovery studies.