This study investigates whether culture plays a major role in determining the corruption levels of countries. The cultural dimensions of Hofstede’s model and the worldwide level of corruption provided by the Corruption Perceptions Index were used. A cross-country survey of 98 countries was conducted using ordinary least squares (OLS) regression. Three of the six main components of Hofstede’s model were found to have a significant influence on corruption, namely power distance, individualism-collectivism, and long- versus short-term orientation. National culture may explain the level of corruption in each of the countries. About half of the level of corruption in countries is explained by the national culture. Governments must acknowledge the role of culture in order to adopt the most appropriate policy decisions to fight corruption.