This paper deals with the problem for synchronization of a nonlinear time delayed complex spatio-temporal network (CSN), modelled by semi-linear parabolic partial differential-difference equations. A boundary controller relying to distributed measurement is designed. Multiple time-invariant delays are firstly considered. By employing Lyapunov’s direct method and Wirtingers inequality, synchronization criteria of the CSN are presented in terms of LMIs. And then, multiple time-varying delays are respectively considered using the boundary controller and synchronization criteria are obtained. Finally, an example illustrates the effectiveness of the proposed method.