The superconducting properties of Nb2PdS5 superconductor have been investigated with Ni doping at Pd site All the bulk polycrystalline Nb2Pd1−xNixS5 (0 = x ≤ 0.10) samples are crystallized in singlephase monoclinic structure. The electrical resistivity and magnetic measurements of Nb2Pd1−xNixS5 (0 = x ≤ 0.15) were carried out to study the variation of superconducting critical parameters with Ni doping. Superconductivity in Nb2PdS5 sample completely disappears for x ≥ 0.15. We observed that the ratio of upper critical field to transition temperature decreases with increasing Ni concentration. Also, the magnetization study of Nb2Pd1−xNixS5 (0 = x ≤ 0.15) samples shows similar superconducting behaviour. In summary, the superconductivity in Nb2PdS5 sample is slightly varying with partial doping of Ni at Pd site in Nb2PdS5 superconductor.