Microarray gene data is widely known for its high dimensionality and volume. The utilization of microarray gene data is increasing now-a-days, owing to the advancement of medical science. Microarray gene data helps in diagnosing diseases quite accurately. However, processing microarray gene data is difficult and is usually not understandable. Taking this challenge into account, this work presents a user-friendly rule based classification model, which is easily understandable and does not demand users to have prior knowledge. The classification rules are formed with the help of cuckoo search optimization algorithm and the rules are pruned by the associative rule mining. Finally, the classification is performed with the help of the pruned rules. The performance of the proposed approach is satisfactory in terms of accuracy, sensitivity, specificity and time consumption.