A hardware and software system for extracorporeal detoxification of blood plasma was developed. The effectiveness of the air barbotage technique for removing carbon tetrachloride from blood plasma and its mixtures with plasma substitutes was investigated. The detoxification efficiency was shown to depend on the characteristics of the obtained foams, including the foam-forming ability, froth factor, dispersity, foam scaffold stability, and syneresis. The program for monitoring and control of extracorporeal detoxification of blood plasma was tested. Physical and mathematical models of toxicant excretion in the process of extracorporeal blood purification were elaborated. The mathematical model was verified; the theoretical and experimental data were shown to be in good agreement.