A major milestone in the treatment of complex retinal detachment was the development of heavy fluids as intraoperative short-term tamponades. Since the introduction liquid perfluorocarbons and hydrofluorocarbons are particularly noteworthy. Irrespective of the suitability of the substances in principle, the purity during the manufacturing process is a decisive factor that determines possible side effects. Also, the direct exchange with silicone oil can lead to mixing with disadvantageous results. Retinal surgeons should be informed about the properties of the tamponades used. Despite all expectations, the heavy liquids could not become established compared to silicone oil as a long-term tamponade, which is why their domain is the short-term intraoperative use.