This study presents an optimization procedure for the design of a one-piece zirconia ceramic dental implant that uses finite element simulation with dynamic loads and experimental validation using a fatigue test. The key dimensions of the implant’s shape are the factors for the simulation. Their effect on micromotion is determined using a uniform design of experiment. The Kriging interpolation method and a genetic algorithm (KIGA) are used to optimize the geometric features, in order produce an optimized one-piece dental implant model. The model is fabricated using a three-dimensional slurry printer. The lifetime of the zirconia implant is evaluated using a fatigue test. The numerical result for the objective function shows that the micromotion for the optimized dental implant is 27.58 μm, which is less than the value of 72.62 μm for the original numerical prediction. The safety factor also increases to 1.54 from 1.16. This demonstrates that the optimized dental implant is better than the original design because the degree of micromotion is much lower than the stability threshold. The fatigue test also shows that the safety factor increases to 1.54. Therefore, the proposed procedure produces a dental implant with an optimized shape.