The importance of ceramics in medicine has accelerated and become increasingly more sophisticated, in part due to advances in cell biology and tissue engineering. Improvements in ceramic processing technologies have also led to a great interest in bioceramics. Nowadays, bioceramics are used extensively to repair defective tissues and organs. This paper discusses the manufacturing, chemical, and physical characterization of three-dimensional porous scaffolds developed for the repair of skeletal defects in tissue-engineering applications. Our attention was focused on the manufacturing of porous bioceramic three-dimensional scaffolds that, while allowing loading transmission through the bulk material, improve interface cohesion between natural bone and a synthetic scaffold. We have tested different manufacturing processes for the mixing of the raw materials, a Ca-P ceramic and two different kinds of polymeric powders, namely, a cellulose-derived polymer and a polyamide, in terms of the final product’s morphological resemblance to spongy bone tissue. Scanning electron microscopy (SEM) was used to visualize the scaffold morphology, and pore size distribution was analyzed in a mercury intrusion porosimeter.