For the diagnosis, disease stratification, treatment planning, and prognosis of different cardiac diseases clinically presenting with myocardial dysfunction and regional or global ischemia, respectively, the accurate and reproducible determination of left-ventricular myocardial function is fundamental. Heart failure afflicts about 4.5 to 5 million people in the United States, with more than 500,000 new cases developing each year. Clinical assessment with regard to left-ventricular function is generally difficult; although an entirely normal electrocardiogram (ECG) provides a close correlation to normal systolic function, electrographical findings are nonspecific. The ideal imaging modality to determine left-ventricular function in a clinical setting would be noninvasive, accurate, reproducible, easily available, as well as cost and time effective (1–3).