The reactions of the intermetallic compounds Sc2Al and Sc2Ni with hydrogen have been investigated. The results demonstrate that Sc2Ni reacts with hydrogen even at room temperature, to form amorphous Sc2NiH5. The reaction is irreversible at room temperature. Vacuum extraction of hydrogen between room temperature and 900°C leads to partial decomposition of Sc2NiH5 and the formation of crystalline ScH2 and ScNi2. Sc2Al is nonreactive with hydrogen at room temperature. Heating at a hydrogen pressure of 5 MPa leads to Sc2Al hydrogenolysis starting at 225°C and the formation of ScH2 and metallic Al.