Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been an important therapy in the treatment of a large number of cutaneous pathologies for more than three decades. Objective: In this retrospective review, we document the use of NSAIDs in more than 15 common and uncommon dermatoses, including acne, psoriasis, sunburn, erythema nodosum, cryoglobulinemia, Sweet's syndrome, systemic mastocytosis, as well as urticarial, livedoid, and nodular vasculitis. NSAIDs act mainly by inhibiting prostaglandin synthesis by the cyclooxygenase (COX) pathway. Conclusion: Recent studies link prostaglandin to cutaneous carcinogenesis, thus expanding the dermatologic use of NSAIDs. They may be effective in the treatment and prevention of non-melanoma skin cancer, and specific COX-2 inhibitors promise safer, broader, long-term use of these pharmacologically innovative drugs. Antcdents: Depuis plus de trois dcennies, les anti-inflammatoires non strodiens (AINS) ont jou un rle important dans le traitement de nombreuses dermatoses. Objectifs: Dans cette tude rtrospective, nous documentons l'usage d'AINS dans plus de 15 dermatoses frquentes et peu frquentes, notamment l'acn, le psoriasis, les coups de soleil, l'rythme noueux, la cryglobulinmie, le syndrome de Sweet, la mastocytose systmique ainsi que les vascularites urticariens, livdodes et nodulaires. Les AINS agissent principalement en inhibant la synthse des prostaglandines par les voies d'accs de la cyclooxygnase. Conclusion: Des tudes rcentes ont li la prostaglandine a la carinogense cutane, largissant ainsi l'usage des AINS en dermatologie. Les AINS peuvent tre efficaces dans la prvention et le traitement des cancers de la peau bnins. Les inhibiteurs de COX-2 promettent de produire des mdicaments innovateurs plus srs, usage plus tendu, plus.