Development of new materials is needed for numerous applications in engineering, medical, and scientific arenas. In this chapter, we describe some of our research efforts that focus on developing strategies and tools for high throughput production and screening to create advanced biomaterials and chemical sensors. Using our developed tools, we are able to produce and screen a wide array of materials in a short period of time. In several current embodiments, the system can readily produce and fully screen 100–1,000 samples/day. Our developed automated systems can provide results with minimal user input, yet with better precision and accuracy in comparison to traditional manual methods.