Progress in the treatment of HIV infection over the past decade has resulted in dramatic reductions in morbidity, mortality and health care utilization as more effective treatment regimens have been developed and simpler schedules of drug administration have been devised [1, 2]. As more effective regimens have provided durable suppression of viral replication, it has become clear that reversal of disease progression can be achieved even in persons with advanced HIV infection [3]. It is now possible to achieve at least transient interruption of disease progression in almost all patients who have received no prior antiretroviral therapy, and who are therefore responsive to most available antiretroviral drugs [4].