Parallel to the increasing incidence of symptomatic rotator cuff tears (RCTs), the number of surgical repair procedures for rotator cuff (RC) repair is also increasing. Despite modern fixation techniques, the number of re-ruptures is still relatively high. Because most RCTs occur from intrinsic degeneration, it appears promising to support healing by adding biologic factors, e.g., growth factors, stem cells, or matrices. Data for matrix use and stem cell addition are inconsistent at this time. In vitro data support a positive effect of at least growth factors on cell proliferation and matrix expression even in degenerative RC tissue. Autologous growth factors with a positive effect on tenocytes can easily be delivered to a surgical reconstruction site by using platelet-rich plasma (PRP) products during arthroscopic or mini-open procedures. Several reliability studies show easy and safe technical handling of these techniques without an increase in complications. However, prospective randomized studies with strong statistical power are missing at this time.