SummaryFluid inclusions from two Mesoproterozoic, metamorphosed layered intrusive complexes, Niquelndia and Barro Alto, Gois State, Brazil record multiple fluid influx events from the magmatic to granulitic and retrograde metamorphic stages. 1.The oldest inclusions contain high density CO2N2CH4 and are found as primaries in plagioclase and orthopyroxene in mafic granulite with homogenization temperatures between 48 and 28C. These inclusions may correspond to the early, magmatic stage. This type was found in samples from both the Niquelndia and the Barro Alto complexes. 2.Intragranular, relatively high density CO2+N2 inclusions (Th between 33 and 26C) together with decrepitated and reequilibrated N2 inclusions (Th between 160 and 151C) in the rock-forming minerals can be associated with the granulite facies metamorphism. Such inclusions were found only in the Barro Alto complex. 3.Transgranular, high density, CO2N2 inclusions (93% CO2 and 7% N2, according to Raman analysis, with Th between 66.6 and 50.4C) as well as the low density, secondary CO2N2CH4 inclusions (Th between 13.0 and +18.7C) and the H2ONaClCaCl2 hypersaline inclusions (with halite dissolution temperature between 132 and 354C, and Th between 212 and 490C) are attributed to different fluid influx events during the retrograde metamorphism. This inclusion type can be found both in the Niquelndia and in the Barro Alto complexes. The fluid inclusion textures and compositions show several stages of fluid evolution. The fluid inclusion measurements and the geothermobarometric data indicate an anticlockwise P-T path for both the Barro Alto and the Niquelndia complexes.