This paper presents a guideline which uses the concepts of design for manufacturing and assembly methodology for specific application on design and manufacturing of aircrafts. The main goal of this guideline was to orient the engineers during the aircraft development phases, such that a better aircraft design is achieved. The guideline comprises a set of tables to drive the engineers for a better evaluation of manufacturing processes, assembly, maintenance and human factors (ergonomics). It aims to improve the manufacturing and assembly for easy manufacturing of parts that build the aircraft with low costs, high quality and the best optimized condition. A case study is shown to testify the advantages and benefits achieved when the proposed guideline tool is used.