Abstract. Laser microdrilling of healthy human enamel and dentine using 300fs pulses at a wavelength of 615nm and 3Hz repetition rate leads to an enhanced structuring quality in comparison with nanosecond-laser results. Microcracking and damage to neighboring tissue can be reduced. Ablation threshold fluences for 100 laser pulses of 0.3Jcm-2 (human dentine), 0.6Jcm-2 (human enamel) and 0.8Jcm-2 (single crystalline fluoroapatite) could be determined. Ablation depths per pulse below 1m were observed.