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Ghrelin production was originally demonstrated in human endocrine cells of the gastric body and of the pituitary gland, but was rapidly shown to occur also in several other normal and neoplastic cells. Most endocrine tumors were found to contain ghrelin, as detected by both immunohistochemistry or mRNA analysis. Not only pituitary adenomas and gastro-entero-pancreatic carcinoids produce ghrelin, but...
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