Frozen sections of the pancreas are performed for tumor confirmation and to assess resectability and margin status. Accurate frozen section diagnoses are important to help guide the surgical procedure. Diagnostic difficulties in pancreatic frozen sections are related to technical and morphological factors, with the main problematic differential diagnosis being between chronic pancreatitis and duct adenocarcinoma. Most of the histologic features useful in frozen sections are similar to those useful in small biopsies, but the diagnosis is more challenging due to frozen artifacts and time constraints.