The quay crane scheduling problem (QCSP) is at the basis of a major logistic process in maritime container terminals: the process of discharging/loading containers from/on berthed vessels. Several groups of containers, laying in one or more stowage portions of a containership, have to be assigned to multiple cranes and discharge/loading operations have to be optimally sequenced, under some complicating constraints imposed by the practical working rules of quay cranes. The QCSP has been the object of a great deal of research work since the last decade and it is focused in this paper, with the aim of consolidating a promising solution approach based upon the combination of specialized branch & bound (B&B) and heuristic algorithms. A cost-effective solution technique that incorporates the local branching method within a refined B&B algorithm is proposed and its effectiveness is assessed by numerical comparisons against the latest algorithm available in literature.