1% Pt/Al2O3 and 1% Pt/CeO2 are markedly activated by the deposition of a large quantity of FeO x , about 100 wt% in Fe with respect to the supports. In contrast, the activity of a Ru/Al2O3 catalyst was completely suppressed by the deposition of FeO x , but a Ru-Pt/Al2O3 was markedly activated by the FeO x . The activation depends on the sequence of the deposition, that is, no pronounced activation was observed on the Pt supported on a FeO x /Al2O3 as well as on the Pt codeposited with a small amount of Fe on Al2O3, that is, the activity was almost equal to that of the Pt/Al2O3. The XPS analysis of the Pt/CeO2 and FeO x /Pt/CeO2 proved that the Pt is effectively covered with the FeO x . Selectivity for the oxidation of CO in H2 was also improved on the FeO x /Pt/Al2O3 and FeO x /Pt/CeO2 catalysts and it is rather independent of the conversion. In conformity with the feature of the FeO x /Pt/Al2O3 and FeO x /Pt/CeO2 catalysts, we deduced that the deposited FeO x is activated by the Pt and the FeO x is responsible for the selective oxidation of CO.