In recent years, there has been a conceptual shift from a merely biomedical approach in disease treatment to a psychosomatic consideration of the entire person and his/her quality of life; with the goal of more effective patient management. The term “psychosomatic” refers to the assumption that mind and body are inseparably linked, and that the person invariably functions and reacts as an integrated mind–body unit. The application of psychosomatic research tools is providing new insight in the setting of endocrine disorders, as it has in other fields of medicine. This chapter reviews the psychosocial aspects in Cushing’s syndrome, characterized by an array of debilitating symptoms and clinical features, in which psychological manifestations play a prominent part, and which may persist despite correction of the underlying biochemical disorder.