The present study was carried out from January to June 2011 in Al-Manathera General Hospital in Al-Manathera City, Iraq. The study aimed at comparing between bacteriological etiologic agents of otitis media and urinary tract infection (UTI). The study revealed that, from the 130 specimens from outpatients (65 ear swab from patients infected with otitis media and 65 urine specimens from patients infected with UTI), there were 60 bacterial isolates from patients infected with otitis media (36 males, 60 %, and 24 females, 40 %) with five no-growth specimens. Pseudomonas aeruginosa was the most prevalent bacteriological etiologic agent of otitis media (25 isolates, 41.666 %), while from the 65 urine specimens from patients suffering from UTI, there were 65 bacterial isolates (24 males, 36.923 %, and 41 females, 63.077 %). Klebsiella pneumoniae was the most prevalent etiologic agent of UTI (27 isolates, 41.53 %). Nitrofurantoin was active against all the otitis bacterial isolates and the UTI isolates, while Ampicillin and Penicillin were not active against most of bacterial isolates.