The use of the method of operative monitoring of the functional state of the workers by pupillometric findings to examine health of workers engaged in the process of chemical weapons destruction is suggested. To register pupillary responses and spontaneous changes of the pupillary diameter, the Special Design Engineering Office “Biophyspribor” in collaboration with the Research Institute of Hygiene, Occupational Pathology and Human Ecology has worked out several modifications of pupillometers built on modern components with the use of personal computers to process the obtained data in real time.