Chirality in self-organizing media can yield a variety of novel mesophases with unique properties and structures. At high levels of chirality, however, non-linear effects come into play. The effects of chirality in self-assembled structures can compete successfully with those of conventional self-assembling properties to yield frustrated structures. For instance, the desire for rod-like molecules to form layered mesophase structures can be frustrated by the molecules’ needs to form twisted structures. This can result in a defect stabilized phase being formed, where screw dislocations punctuate the normal self-organized phase in a similar way to how lines of flux punctuate the superconducting phase of a type II superconductor. This novel frustrated structure is called the Twist Grain Boundary Phase, its discovery links the physical understanding of liquid crystals to that of superconductors.