Background. The American Cancer Society (ACS) is interested in facilitating colorectal cancer screening (CRCS) in primary care. Methods. Similar clinics were assigned randomly to 1 of 3 CRCS arms: (1) usual care, (2) exam-room posters designed by the ACS; and (3) posters plus patient reminder calls from an ACS volunteer. Results. Compared to patients due for screening in Arm 1, the odds ratio for getting CRCS in Arm 2 was 1.04 (95% confidence interval [CI], 0.81–1.34), P value not significant; in Arm 3, it was 1.49 (95% CI, 1.16–1.90), P value < .001. Conclusions. Exam-room posters plus patient reminder calls from the ACS can increase CRCS in primary care.