The computational speech science portal is a highly intensive data sharing and remote visualization environment that uses e-Science technologies to support scientists in accessing distributed databases and visualization resources for solutions of the physics of human speech problems. These recourses include input files specifying the human oral cavity geometry of speech, and proprietary software and hardware for visualization and data sharing of computational fluid dynamics (CFD) results. Through a Web-based grid portal, a user can access these resources and collaboratively visualize the results of the CFD simulation and sharing the result of it. Thus, the portal allows users to use the e-science infrastructure to share resources among geographically distributed partners in order to execute large-scale CFD simulations and to collaboratively analyze and visualize the results. However, among geographically distributed partners, large-scale data normally cannot be transferred in a short period of time because of the long round-trip time of the TCP protocol. This chapter describes the web-based portal, built on the Gridsphere framework. The portal is composed of a number of JSR-168 compliant portlets that deploy services at the back end for the management of distributed resources and for the invocation of services for visualization. The chapter also describes how high-speed data transfer is achieved through the e-science infrastructure.