Background
In rare cases, hypothalamic-pituitary dysfunction can be associated with an extraordinarily active non-alcoholic steatohepatitis (NASH) and subsequent liver cirrhosis.
Case report
The two young adult patients described in this report presented with NASH together with advanced liver fibrosis and cirrhosis 5 and 19 years, respectively after resection of a craniopharyngeoma.
Conclusions
In young patients and children with active steatohepatitis, an association with hypothalamic-pituitary dysfunction should be excluded. Especially hypothalamic-pituitary-related NASH tends to develop rapidly into liver cirrhosis.