The performance of a network protocol depends highly on the configuration of its parameter setting. Typical installations consider just a static setup that works well on average. The Organic Network Control (ONC) system provides a possibility to adapt the configurations of network protocols to environmental changes dynamically at runtime. Such rapidly changing conditions can be found e.g. in mobile ad-hoc networks (MANets), since nodes that form the direct neighbourhood are moving and the sending distance is restricted. Thus, MANets are a promising application domain for the ONC system. This chapter describes how ONC is applied to the control of MANet protocols and demonstrates the positive effect caused by the on-line adaptation. Furthermore, a collaboration mechanism is introduced that has been developed to alleviate the impact of some high-effort tasks of the system. Instead of fulfilling tasks on their own, neighboured nodes can share their knowledge and take over some responsibilities from each other.