The aim of this chapter is to present a stratiographic and geomorphic analysis of the Holocene historical paleowetland records and to study the factors that involve high Andean wetland degradations related to human settlements in the Southern Altiplano of Argentina. In order to obtain the records and to test the hypothesis we proposed a cross-disciplinary study with methods and techniques from archaeological, geological and biological sciences, but in an adequate and integrated approach. This paleohydrological study may influence on decisions that have an impact on the current regional economy, for instance in the case of ill used technology and therefore degrading the wetlands or the possibility of reinforcing land reactivation of former productive areas.