There are four metallogenic belts in China consisting of mid-low temperature hydrothermal deposits. They are commonly accompanied by oil, gas or/and coal-bearing basins. Systematic geochemical research of representative mid-low temperature hydrothermal deposits with super-large or large tonnages, such as the Xikuangshan Sb deposit and the Woxi Au-Sb deposit in the Hunan Province, reveal that ore-forming materials were mostly derived from the Proterozoic basement and that large-scale fluid flow in ore-controlling strata was driven by the Yanshanian tectonicmagmatic event. The hydrothermal systems caused by large-scale fluid flow involved a large basin comprising at least three tectonic units (Jinningian, Caledonian and Yanshanian) with a thickness of thousands of meters. These deposits developed two types of primary geochemical anomalies, an external-source and an authigenous-source, depending on the source of ore-forming materials. Depleted zones of ore-forming elements in regions with negative anomalies near ore bodies characterize the authigenous-source geochemical anomaly around the deposits. The variation coefficient of ore-forming elements and cumulative probability plots are effective methods to recognize authigenous-source geochemical anomalies. The results show that since the Late Triassic, regional epeirogeny to subsequent widespread Yanshanian granitic magmatic plutonism in southern China, hydrothermal mineralization and large-scale geochemical zoning were generated in response to events and phenomena relating to thermal uplift driven by asthenospheric upwelling that resulted from the breakup of the Pangean supercontinent.