A series of full-scale explosion suppression experiments were conducted in a compartment. The suppression performance of three extinguishing systems with two suppressants for the deflagration-type explosion was studied. The impact of agent discharge direction, the presence of an obstacle and the use of additives on suppression performance were investigated with extensive data collection and analysis. The negative aspects and toxicity issues associated with the protection systems are also addressed in the paper. The three extinguishing systems evaluated in this project were a high pressure HFC-227ea (FM-200) extinguisher, a hybrid gas generator with FM-200, and a hybrid gas generator with water, with full-system hardware including optical flame sensors and electronic controllers. The experimental results showed that the explosion in a compartment originating from a fuel spray was a serious threat to any occupant in the compartment and could cause major damage to equipment, but, the explosion generated in the experiments was controlled or extinguished by appropriate extinguishing systems.