Although seizures have been described since ancient times, it is surprising how scant are the descriptions of what today is clearly identified as status epilepticus (SE). Perhaps the earliest reference to the condition of epilepsy and prolonged, ongoing seizure activity—SE—may be found in the Sakikku Cuneiform Tablet (Fig. 1), which notes
If the possessing demon possesses him many times during the middle watch of the night, and at the time of his possession his hands and feet are cold, he is much darkened, keeps opening and shutting his mouth, is brown and yellow as to the eye. It may go on for some time, but he will die. (XXV–XXVI Tablet Obverse 718–612 bc)