The neutron total cross-sections and resonance parameters of Niobium (Nb) and Palladium (Pd) were measured in the neutron energy regions from 0.1 eV to 100 eV by using the time-of-flight method at the Pohang Neutron Facility, Korea, which consists of an electron linear accelerator, a water-cooled Tantalum (Ta) target with a water moderator, and a 12.06 m long time-of-flight path. A 6Li-ZnS(Ag) scintillator with a diameter of 12.5 cm and a thickness of 1.6 cm was used as a neutron detector, and high purity natural Nb and Pd metallic sheets with thickness of 15 mm (0.0833 atoms/barn) and 1 mm (0.0068 atoms/barn) respectively, were used for the neutron transmission measurements. The notch filters composed of Cobalt (Co), Indium (In), and Cadmium (Cd) were used to estimate the background level and also to calibrate energy. In order to reduce the gamma-ray background from Bremsstrahlung and from neutron capture, we employed a neutron-gamma separation system based on their different pulse shapes. The resonance parameters of natNb and natPd were obtained from the transmission ratio by using the SAMMY code, which utilizes both Doppler and resolution broadening effects and Bayes’ generalized least squares technique. The present measurements were compared with the existing experimental and the evaluated reactions data files.