By means of the hypocenter distribution and focal mechanism of Wuding M S=6.5 earthquake sequence occurred in 1995, the space orientation and activity characteristics of focal fault of Wuding earthquake have been studied from the three-dimensional space-time process. The results indicate that the focal fault of Wuding earthquake is a subsurface, NWW-trending, upright and right-lateral strike slip fault which is consistent with the intensity distribution in the meizoseismal region. Although the large-scale NS-trending Tanglang-Yimen active fault passes through the earthquake region, it is irrelevant to the M S=6.5 Wuding main earthquake. Since the relationship between the strong earthquake and the shallow geological active fault can not be determined, the crustal deep structure should be studied. The method proposed in the paper can be used to distinguish the focal fault in the deep crust.