The health and sanitary monitoring (HSM) in the vicinity of extremely hazardous destruction and storage facilities, and first of all at the territory where protective measures are conducted, should be of a specific type. Prompt and adequate solution of urgent problems of public health protection in the system of health and sanitary monitoring is achieved by developing the multilevel automated software-hardware unit on the basis of individual data bases and of monitored human environment factors. The systems and methods under consideration are now introduced at the area of the chemical weapons destruction facility in the settlement of Shchuch’ye in the Kurgan region.