Earlier studies found that self-reported posttraumatic stress disorder (PTSD) symptoms are correlated with negative appraisals of symptoms and with neuroticism. It is unclear whether the latter two are associated. Possibly, an overarching trait such as neuroticism mediates the relationship between PTSD symptoms and negative appraisals of symptoms. Data from a previous study (see I. M. Engelhard, M. A. van den Hout, M. Kindt, A. Arntz, & E. Schouten, 2003) were used in the present effort to address these issues. Neuroticism scores were obtained from 1,372 pregnant women. One hundred and twenty-six women experienced a pregnancy loss, and 117 of them were assessed for PTSD symptoms and negative appraisals of symptoms. The 3 variables of interest were all significantly correlated. The data indicate that negative appraisals of symptoms explain and predict PTSD symptoms independently of neuroticism.