The detailed analysis of the isotope-geochronological and isotope-geochemical data obtained in recent years by different researchers, including the authors of this study, is performed for the metamorphic formations of the Sredinny Range in Kamchatka formed within the Cretaceous sedimentary basin of the continental margin. It is concluded that all metamorphic complexes have the same age. They do not show stratification by the age of their formation, but the sequence of metamorphic facies from the ultra-high-temperature in the core of the metamorphic zone to the low-temperature on the flanges, which resulted from the metamorphic processes, granitization, and the formation of granite-gneiss domes ∼52 Ma ago. These processes resulted in the sharp uplift of the central parts of the metamorphic zone of the Range and their intense erosion, controlling widespread relationships between the deeply and weakly metamorphosed formations.