A method based on matrix solid-phase dispersion (MSPD) and liquid chromatography–electrospay ionization–mass spectrometry used to analyze fifteen fungicide residues in fruits and vegetables is described. The method required only 0.5 g of sample, C18-bonded silica was used as dispersant sorbent, and ethyl acetate was used as eluting solvent. Fortified recoveries in apple, orange, banana, lettuce, grape and tomato samples ranged from 71% to 102% and relative standard deviations were less than 13% with fortified levels of 0.03–1.5 mg kg−1. Detection and quantification limits were 1~30 μg kg−1 and 4~100 μg kg−1, respectively, with linear calibration curves extending up to 15 mg kg−1. The analytical characteristics of MSPD compared very favorably with those found for a classical multiresidue method: the quick, easy, cheap, effective, rugged, and safe (QuEChERS) method. The method was applied to determine the fungicides in real samples. Liquid chromatography–tandem mass spectrometry (LC–MS–MS) was used as confirmatory tool for positive samples.