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The immobilization of DNA on different solid supports has become an important issue in different fields ranging from medicine to analytical chemistry and, more recently, molecular electronics. Among the different immobilization procedures, adsorption is the simplest and the easiest to automate, avoiding the use of procedures based on previous activation/modification of the substrate and subsequent...
The covalent immobilization of biomolecules on surfaces is of great interest for many medical and bioanalytical applications. Currently, there is a wide range of procedures available for the modification of surfaces to achieve covalent immobilization. Self-assembled monolayers (SAMs) are easy to generate, offer a high level of flexibility and can be precisely modified on a molecular level. Therefore,...
We describe here a simple preparation of a DNA-lipid complex that is soluble in organic media, and preparations of DNA-aligned thin films from the cast-stretching method and the Langmuir--Blodgett (LB) method. The DNA-lipid complex in which counter cations of phosphate anions are changed to cationic lipophilic amphiphiles was prepared by simply mixing aqueous solutions of DNA and cationic amphiphiles...
The immobilization of nucleic acids onto substrates in array fabrication is a complex process involving three major steps: (i) the chemical modification of the arrayed material in such a fashion that it can interact with complementary functionalities present on the substrate to form a stable bond; (ii) the coating of the support surface with adequate functional groups to allow specific binding and...
Although most in vivo biomolecular recognition occurs in solution, in many practical situations (e.g., diagnostics, drug discovery and biosensing) biomolecular recognition occurs between “target” biomolecules immobilised on surfaces and “probe” complementary biomolecules approaching the surface from solution. DNA-based devices are by far the most common biomolecular and cellular planar biodevices...
Immobilization strategies for the attachment of nucleotide probes to both microarrays and microfabricated interdigitated electrodes differ to address the specific requirements for optical and electrochemical detection, respectively. The DNA immobilization chemistry dictates how the probe molecule is presented to its complement during hybridization and thereby contributes significantly to the final...
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