The paper discusses the complexity involved in considering targeted product users’ anthropometric variation in multivariate design problems, such as the design of workplaces or vehicle interiors. The authors argue for the advantages of offering designers a number of predefined digital human models to incorporate in the CAD product models. A study has been carried out in order to illustrate the use of predefined digital human models in vehicle interior design by using the Digital Human Modelling (DHM) tool RAMSIS. The paper takes a designer’s view of digital human modelling and illustrates how DHM can be of great value in the design process, but also considers what implications this has on the functionality and usability of DHM tools.