The methods of gas-liquid chromatography and mass-selective detection were used to determine the composition of the volatile fraction of plant extracts included in herb mixtures used for treating parodontal disease. The following marker substances were found: naphthalene derivatives for pot marigold, furan derivatives for trifid bur-marigold and burnet, and the specific terpenoids for licorice, milfoil, and wild marjoram. All the plants used in the herb mixture, except for pot marigold and cinquefoil, were analyzed (ion-exclusion chromatography) for the content of lower carboxylic acids. It was established that the specific acids for the wild marjoram and licorice are ascorbic and the succinic acids, respectively.