In this paper an analysis has been made to study heat and mass transfer in two-dimensional stagnation-point flow of an incompressible viscous fluid over a stretching vertical sheet in the presence of buoyancy force and thermal radiation. The similarity solution is used to transform the problem under consideration into a boundary value problem of nonlinear coupled ordinary differential equations containing Prandtl number, Schmidt number and Sherwood number which are solved numerically with appropriate boundary conditions for various values of the dimensionless parameters. Comparison of the present numerical results are found to be in excellent with the earlier published results under limiting cases. The effects of various physical parameters on the boundary layer velocity, temperature and concentration profiles are discussed in detail for both the cases of assisting and opposing flows. The computed values of the skin friction coefficient, local Nusselt number and Sherwood number are discussed for various values of physical parameters. The tabulated results show that the effect of radiation is to increase skin friction coefficient, local Nusselt number and Sherwood number.