We present the main findings of two recent studies using high-resolution MHD simulations of supersonic magnetized shear flow layers. First, a strong large-scale coalescence effect partially countered by small-scale reconnection events is shown to dominate the dynamics in a two-dimensional layer subject to Kelvin-Helmholtz (KH) instabilities. Second, an interaction mechanism between two different types of instabilities (KH and current-driven modes) is shown to occur in a cylindrical jet configuration embedded in an helical magnetic field. Finally, we discuss the implications of these results for astrophysical jets survival.