Code Division Multiple Access (CDMA) using Direct Sequence (DS) spread spectrum modulation provides multiple access capability essentially thanks to the adoption of proper sequences as spreading codes. The ability of a DS-CDMA receiver to detect the desired signal relies to a great extent on the auto-correlation properties of the spreading codes associated to the users; on the other hand, multi-user interference rejection depends on the cross-correlation properties of all the spreading codes in the set chosen. This paper provides preliminary results about the adoption of particular binary sequences, the De Bruijn ones, as spreading codes in DS-CDMA schemes. Though preliminary, the evaluations herein proposed encourage further investigation activities that are currently being developed.