The Johns Hopkins Talent Search model, which was pioneered in the early 1970s by Professor Julian Stanley, has now spread to countries around the world. Also known as the MVT:D4 model of talent development, the power and efficacy of this approach for identifying and serving students with above-grade-level mathematical and/or verbal reasoning abilities have been well validated. Researchers at Johns Hopkins, as well as at other universities who use this model, have contributed greatly to our knowledge and understanding of the needs of gifted students. They have also developed and evaluated numerous strategies for meeting the educational needs of students with advanced abilities. This chapter summarizes the history of the Talent Search, its principles and practices, and the research that has been done on Talent Search students.