Sphincter of Oddi dysfunction (SOD) is a functional gastrointestinal disorder (FGID), which causes pancreatobiliary-type pain, cholestasis, and/or pancreatitis. Only a few studies have assessed the level of psychological distress in this population compared to healthy subjects or patients with other gastrointestinal disorders. In this study, we examined the self-reported level of psychological distress and certain psychiatric symptoms of SOD patients, and we compared them to depressed patients as well as healthy subjects. The results indicate that SOD patients have significantly lower levels of global and specific symptoms compared to depressed patients. When compared to healthy subjects, SOD patients expressed significantly higher levels of irritability–oversensitivity, and there was a trend toward higher levels of somatization.