This article introduces different evaluation methods in the field of quality of life: open interview, standardized measure through questionnaires, individual evaluation, and defining advantages and limits of each of these. In a second part, the different steps necessary to construct and to validate such a standardized quality of life tool are described, showing the permanent need to work with patients and teams’ expertise in the field. Cross-cultural adaptation and validation questions are identified. These tools are shown to be both useful in the field of clinical research and important to help better describe individual clinical pathways, with the permanent aim to increase our understanding of the cancer patient’s problems and needs.