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Binding of bacterial toxins or adhesins to oligosaccharide receptors on the surface of eukaryotic cells is a crucial step in the pathogenesis of many infectious diseases. Thus, blockade of such interactions is a promising anti-infective strategy. This can be achieved by engineering expression of molecular mimics of host oligosaccharides on the surface of probiotic bacteria. The outer core region of...
Enteric disorders (encompassing both enteric infections and inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease) are a significant public health issue worldwide. Enteric infections can be caused by bacteria, fungi, parasites and viruses, while the aetiology of inflammatory bowel disease remains to be elucidated. With increases in antibiotic resistance, the emergence of multidrug...
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